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Lisa D Aimone Selected Research

6- (4- (3- (2- methylpyrrolidin- 1- yl)propoxy)phenyl)- 2H- pyridazin- 3- one

1/2012CEP-26401 (irdabisant), a potent and selective histamine H₃ receptor antagonist/inverse agonist with cognition-enhancing and wake-promoting activities.
7/2011Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist.

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Lisa D Aimone Research Topics

Disease

9Neoplasms (Cancer)
06/2012 - 12/2003
2Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma)
03/2012 - 12/2010
1Sleep Wake Disorders
01/2016
1Genetic Translocation (Chromosomal Translocation)
03/2012
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
03/2012
1Neuroblastoma
03/2012
1Schizophrenia (Dementia Praecox)
01/2012
1Cognitive Dysfunction
07/2011

Drug/Important Bio-Agent (IBA)

4Anaplastic Lymphoma KinaseIBA
05/2012 - 12/2010
3Phosphotransferases (Kinase)IBA
06/2012 - 03/2007
2Tyrosine (L-Tyrosine)FDA Link
06/2012 - 03/2012
26- (4- (3- (2- methylpyrrolidin- 1- yl)propoxy)phenyl)- 2H- pyridazin- 3- oneIBA
01/2012 - 07/2011
13- (1'- cyclobutylspiro(4H- 1,3- benzodioxine- 2,4'- piperidine)- 6- yl)- 5,5- dimethyl- 1,4- dihydropyridazin- 6- oneIBA
01/2016
1CrizotinibIBA
05/2012
1CEP-28122IBA
03/2012
1Pharmaceutical PreparationsIBA
03/2012
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2012
1CytokinesIBA
01/2012
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2012
1Antipsychotic Agents (Antipsychotics)IBA
01/2012
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
12/2011
1Histamine (Histamine Dihydrochloride)FDA Link
07/2011
1EnzymesIBA
12/2010
1Proteins (Proteins, Gene)FDA Link
12/2010
1Insulin ReceptorIBA
12/2010
1compound 21IBA
12/2003
1EstersIBA
12/2003
1ProdrugsIBA
12/2003
1dimethylglycineIBA
12/2003

Therapy/Procedure

3Therapeutics
03/2012 - 01/2012